Document Detail

The effect of 7 years of intense exercise training on patients with coronary artery disease.
MedLine Citation:
PMID:  3598003     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the effects of long-term exercise training on maximal aerobic exercise capacity, evidence of myocardial ischemia and plasma lipid-lipoprotein concentrations in patients with coronary artery disease. Nine men with coronary artery disease, aged 57 +/- 2 years, who had completed 12 months of supervised intense exercise training were restudied after 6 additional years during which they continued to exercise. The first 12 months of training resulted in a 44% increase in maximal oxygen consumption (VO2max) from 25.0 +/- 1.3 to 35.9 +/- 1.5 ml X kg-1 X min-1 (p less than 0.001). The VO2max after 6 additional years (total 7 years) of intense training was 36.8 +/- 2.4 ml X kg-1 X min-1. Plasma high density lipoprotein (HDL)-cholesterol concentration increased from 38 +/- 3 to 45 +/- 4 mg X dl-1 at 12 months and rose further to 53 +/- 5 mg X dl-1 at 6 years of follow-up (p less than 0.05). The atherogenic index (total cholesterol/HDL-cholesterol ratio) decreased from 5.8 +/- 0.4 to 4.9 +/- 0.4 by 12 months (p less than 0.01) and to 4.1 +/- 0.4 after 6 additional years of training (p less than 0.05). Although the maximal heart rate-pressure product was 14% higher after 12 months of training, maximal ST segment depression was significantly less, 0.27 +/- 0.06 versus 0.19 +/- 0.04 mV (p less than 0.05); this improvement was maintained after 6 years of additional training. These data provide evidence that the beneficial effects of a program of intense exercise training can be maintained for long periods in some motivated patients with coronary artery disease who continue to exercise.
M A Rogers; C Yamamoto; J M Hagberg; J O Holloszy; A A Ehsani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  10     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-24     Completed Date:  1987-08-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Coronary Disease / blood,  physiopathology*
Heart Rate
Lipids / blood*
Lipoproteins / blood*
Longitudinal Studies
Middle Aged
Oxygen Consumption
Physical Exertion*
Grant Support
Reg. No./Substance:
0/Lipids; 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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