| The effect of 5-hydroxytryptamine on the potassium exchange of human platelets. | |
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MedLine Citation:
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PMID: 6048996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The concentration of potassium in platelets freshly isolated from nine persons was 74 +/- 4.8 mumole/10(11) platelets (mean +/- S.E.M.).2. The influx of potassium into platelets from citrated plasma at 37 degrees C, estimated with the use of (42)K, was 18.3 +/- 1.6 n-mole/sec. 10(11) platelets.3. When plasma contained 5-hydroxytryptamine (5-HT) at a concentration of about 5 mug/ml., the influx of potassium into platelets was increased for as long as they took up 5-HT. This effect was absent when the concentration of 5-HT was either lower (2 mug/ml.) or much higher (50 mug/ml.).4. The concentration of 5-HT in the platelets did not affect their potassium flux. |
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Authors:
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G V Born |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 190 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1967 May |
Date Detail:
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Created Date: 1967-12-13 Completed Date: 1967-12-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 273-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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drug effects* Humans Potassium / blood* Potassium Isotopes Serotonin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Potassium Isotopes; 50-67-9/Serotonin; 7440-09-7/Potassium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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