| The effect of the 2004 Italian law on outcomes of assisted reproduction technology in severe male factor infertility. | |
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MedLine Citation:
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PMID: 20158983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Italian law regulating assisted reproductive technologies that came into force in 2004 restricts the number of fertilized oocytes per cycle to three, obliges the subsequent transfer of all resulting embryos and prohibits the freezing of surplus embryos. This study evaluates the impact of the law on severe oligozoospermic, cryptozoospermic, obstructive azoospermic and non-obstructive azoospermic patients. Intracytoplasmic sperm injection outcomes of 1066 cycles performed in the 4years before the passing of the law were compared with 804 cycles performed in the 4years after the law came to pass. Globally, analysis of clinical and obstetric outcomes showed a significant decrease in terms of pregnancy and delivery rates per cycle (17.8% versus 10.9% and 14.2% versus 8.5%, respectively) and per embryo transfer (18.8% versus 13.8% and 15.0% versus 10.7%, respectively), and a significant drop in multiple deliveries (35.1% versus 17.6%) in the post-law period. Cryptozoospermic and azoospermic couples were affected by the Italian law more than severe oligozoospermic couples. The results showed that the Italian law limits the efficiency of assisted reproduction treatment in couples with severe male factor. It is hoped that the Italian assisted reproductive technologies law is altered as soon as possible, allowing the insemination of more than three oocytes. |
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Authors:
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G B La Sala; A Nicoli; F Capodanno; I Rondini; M T Villani; F Iannotti |
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Publication Detail:
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Type: Journal Article Date: 2009-10-25 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 20 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 2-10 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Arcispedale Santa Maria Nuova, Viale Risorgimento 80, 42100 Reggio Emilia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Azoospermia / therapy Cryopreservation Female Humans Infertility, Male / therapy* Italy Male Oligospermia / therapy Reproductive Techniques, Assisted / legislation & jurisprudence* Severity of Illness Index* Sperm Injections, Intracytoplasmic / legislation & jurisprudence Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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