| The effect of 2-hydroxypropyl-beta-cyclodextrin on in vitro drug release of steroids from suppository bases. | |
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MedLine Citation:
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PMID: 10071835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 2-hydroxypropyl-beta-cyclodextrin (HPCD) on drug solubility and drug release from suppository bases were studied for dexamethasone (DX), dexamethasone acetate (DXA), hydrocortisone (HC), hydrocortisone acetate (HCA), and prednisolone acetate (PNA). It was found that HPCD significantly increased the aqueous solubility of all five steroids, and the increased drug solubility significantly influenced the drug release from the polyethylene glycol (PEG) base but not from the cocoa butter base. |
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Authors:
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A Usayapant; B R Iyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 25 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-16 Completed Date: 1999-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 387-90 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA. ausaya@midwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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administration & dosage,
chemistry* Cyclodextrins / chemistry* Dietary Fats Diffusion Excipients / chemistry* Polyethylene Glycols Solubility Steroids Suppositories Vehicles beta-Cyclodextrins* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Cyclodextrins; 0/Dietary Fats; 0/Excipients; 0/Polyethylene Glycols; 0/Steroids; 0/Suppositories; 0/Vehicles; 0/beta-Cyclodextrins; 8002-31-1/cocoa butter; 94035-02-6/2-hydroxypropyl-beta-cyclodextrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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