Document Detail

The effect of 2-amino-4-phosphonobutyric acid on the oscillatory potentials of the electroretinogram.
MedLine Citation:
PMID:  2276313     Owner:  NLM     Status:  MEDLINE    
Previous reports have shown that an intravitreal injection of 2-amino-4-phosphonobutyric acid, a glutamate analogue that selectively blocks the photoreceptors' input to the on-bipolar cells, produces a rapid decrease in the amplitude of the electroretinographic b-wave. To our knowledge, the effect of this glutamate analogue has not been examined on the oscillatory potentials. We therefore conducted such a study. A needle electrode was inserted into the anterior chamber of the eyes of seven anesthetized and paralyzed rabbits to record simultaneously the electroretinogram and the oscillatory potentials. These responses were evoked by flashes of white light delivered in mesopic conditions. As expected, an injection of 2-amino-4-phosphonobutyric acid, produced a rapid decrease in the amplitude of the b-wave, while the a-wave was relatively spared. The amplitude of the oscillatory potentials also decreased rapidly. At maximal effect, the electroretinogram essentially consisted of a normal a-wave followed by small oscillations and no evidence of a b-wave. The 100-1000 Hz recording confirmed that the oscillations seen on the postinjection electroretinograms were remnants of the original oscillatory potentials.
P Guité; P Lachapelle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  75     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-03-04     Completed Date:  1991-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  125-33     Citation Subset:  IM    
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
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MeSH Terms
Aminobutyric Acids / pharmacology*
Anterior Chamber
Electroretinography / drug effects*
Photic Stimulation
Vitreous Body
Reg. No./Substance:
0/Aminobutyric Acids; 6323-99-5/2-amino-4-phosphonobutyric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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