| The effect of 17beta-oestradiol on regional blood flow in anaesthetized pigs. | |
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MedLine Citation:
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PMID: 9882757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The present study was designed to investigate the effects of 17beta-oestradiol on the mesenteric, renal, iliac and coronary circulations and to determine the mechanisms involved. 2. In pigs anaesthetized with sodium pentobarbitone, changes in blood flow in the superior mesenteric, left renal, left external iliac and left circumflex coronary arteries caused by intravenous infusion of 17beta-oestradiol at constant heart rate and arterial pressure were assessed using electromagnetic flowmeters. 3. In eight pigs, infusion of 2 microg h-1 of the hormone caused an increase in renal, iliac and coronary blood flow without affecting mesenteric blood flow, left ventricular dP/dtmax (rate of change of left ventricular systolic pressure) and filling pressures of the heart. In four pigs, these vasodilator effects were enhanced by graded increases in the dose of the hormone between 1, 2 and 3 microg h-1; the highest dose also caused an increase in mesenteric blood flow. 4. In five pigs, blockade of muscarinic cholinoceptors and adrenoceptors with the intravenous administration of atropine, propranolol and phentolamine did not affect the vasodilator responses caused by infusion of 2 microg h-1 of 17beta-oestradiol. 5. The increases in renal, iliac and coronary blood flow caused by infusion of 2 microg h-1 of 17beta-oestradiol were prevented, respectively, by the injection of Nomega-nitro-L-arginine methyl ester (L-NAME) into the renal artery (five pigs), the iliac artery (five pigs) or the coronary artery (five pigs). In five pigs, all responses were prevented by injection of L-NAME into all three arteries. In two pigs, injection of L-NAME into the mesenteric, renal, iliac and coronary arteries abolished the vasodilator responses to the infusion of 3 microg h-1 of 17beta-oestradiol. 6. The present study shows that intravenous infusion of 2 microg h-1 of 17beta-oestradiol primarily dilated renal, iliac and coronary circulations and that a higher dose of the hormone also caused vasodilatation in the mesenteric vascular bed. The mechanism of these responses was shown to be nitric oxide dependent. |
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Authors:
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G Vacca; A Battaglia; E Grossini; D A Mary; C Molinari; N Surico |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 514 ( Pt 3) ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-26 Completed Date: 1999-03-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 875-84 Citation Subset: IM |
Affiliation:
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Laboratorio di Fisiologia, Dipartimento di Scienze Mediche, Facoltà di Medicina e Chirurgia di Novara, Università del Piemonte Orientale A. Avogadro, Italy. Vacca@scimed1.med.no.unipmn.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cholinergic Antagonists / pharmacology Coronary Circulation / drug effects Enzyme Inhibitors / pharmacology Estradiol / pharmacology* Female Heart Rate / drug effects Iliac Artery / drug effects Muscarinic Antagonists / pharmacology NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase Type III Regional Blood Flow / drug effects Renal Circulation / drug effects Splanchnic Circulation / drug effects Swine Vasodilation / drug effects Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Antagonists; 0/Enzyme Inhibitors; 0/Muscarinic Antagonists; 50-28-2/Estradiol; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type III |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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