| The effect of the 162 km endurance ride on equine peripheral blood neutrophil and lymphocyte functions. | |
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MedLine Citation:
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PMID: 20731182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strenuous exercise is recognized as a stress, which may induce functional immunodeficiency and increase individual susceptibility to infection. It has been shown in equine athletes, that alterations in leukocyte functions occur after moderate and submaximal exertion, however, no data deal with the effect of extreme physical exertion. In this study, we evaluated leukocyte functions (neutrophil oxidative burst and lymphocyte proliferation activity in response to mitogens) in horses following the CEI 3* 162 km endurance ride. Exercise-induced stress was manifested as neutrophilic leukocytosis and lymphopaenia resulting in a significant increase in neutrophil:lymphocyte ratio. The alterations in neutrophil function were expressed as a lower percentage of the cells undergoing oxidative burst. The spontaneous lymphocyte proliferation was very high, however, the cells failed to respond to mitogens. Although a decrease in lymphocyte proliferation in response to mitogens has been reported previously, the pattern determined in our study was unique. It may suggest that during the extreme physical exercise immune cells receive an excessive stimulation from yet undetermined factor(s), which renders them unresponsive to extraneous mitogens. The differences between alterations in leukocyte activities induced by extreme exertion may reflect the exercise type and duration as well as the training status of the horses. |
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Authors:
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A Cywińska; Z Wyszyńska; R Górecka; E Szarska; L Witkowski; P Dziekan; A Winnicka; A Schollenberger |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polish journal of veterinary sciences Volume: 13 ISSN: 1505-1773 ISO Abbreviation: Pol J Vet Sci Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125473 Medline TA: Pol J Vet Sci Country: Poland |
Other Details:
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Languages: eng Pagination: 279-85 Citation Subset: IM |
Affiliation:
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Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland. anna_cywinska@sggw.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Proliferation Female Horses / blood* Lymphocytes / cytology, physiology* Male Neutrophils / physiology* Physical Conditioning, Animal / physiology* Sports Stress, Physiological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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