Document Detail

An economic evaluation of antihypertensive therapies based on clinical trials.
MedLine Citation:
PMID:  22249479     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Hypertension is a major issue in public health, and the financial costs associated with hypertension continue to increase. Cost-effectiveness studies focusing on antihypertensive drug combinations, however, have been scarce. The cost-effectiveness ratios of the traditional treatment (hydrochlorothiazide and atenolol) and the current treatment (losartan and amlodipine) were evaluated in patients with grade 1 or 2 hypertension (HT1-2). For patients with grade 3 hypertension (HT3), a third drug was added to the treatment combinations: enalapril was added to the traditional treatment, and hydrochlorothiazide was added to the current treatment.
METHODS: Hypertension treatment costs were estimated on the basis of the purchase prices of the antihypertensive medications, and effectiveness was measured as the reduction in systolic blood pressure and diastolic blood pressure (in mm Hg) at the end of a 12-month study period.
RESULTS: When the purchase price of the brand-name medication was used to calculate the cost, the traditional treatment presented a lower cost-effectiveness ratio [US$/mm Hg] than the current treatment in the HT1-2 group. In the HT3 group, however, there was no difference in cost-effectiveness ratio between the traditional treatment and the current treatment. The cost-effectiveness ratio differences between the treatment regimens maintained the same pattern when the purchase price of the lower-cost medication was used.
CONCLUSIONS: We conclude that the traditional treatment is more cost-effective (US$/mm Hg) than the current treatment in the HT1-2 group. There was no difference in cost-effectiveness between the traditional treatment and the current treatment for the HT3 group.
Rosana Lima Garcia Tsuji; Giovanio Vieira da Silva; Katia Coelho Ortega; Otavio Berwanger; Decio Mion Júnior
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  67     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-09-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Nephrology Division, Hypertension Unit, Brazil.
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MeSH Terms
Amlodipine / adverse effects,  economics*
Antihypertensive Agents / adverse effects,  economics*
Atenolol / adverse effects,  economics*
Blood Pressure / drug effects
Drug Costs
Drug Therapy, Combination / economics
Enalapril / administration & dosage,  economics
Hydrochlorothiazide / adverse effects,  economics*
Hypertension / classification,  drug therapy*
Losartan / adverse effects,  economics*
Middle Aged
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Antihypertensive Agents; 114798-26-4/Losartan; 29122-68-7/Atenolol; 58-93-5/Hydrochlorothiazide; 75847-73-3/Enalapril; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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