Document Detail

An economic analysis of anemia prevention during infancy.
MedLine Citation:
PMID:  18760421     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the cost-benefit profile of reticulocyte hemoglobin content (CHr) with hemoglobin (Hb) alone and Hb as a component of the complete blood count (CBC) for detection and treatment of iron deficiency in 9- to 12-month-old infants. STUDY DESIGN: Cohort simulations were used to compare CHr with Hb from a societal perspective. Assumptions included a 9% prevalence of iron deficiency and testing characteristics/costs of CHr, Hb, and CBC (CHr <27.5 pg: sensitivity 83%, specificity 72%, $11; Hb <11 g/dL: sensitivity 26%, specificity 95%, $5; CBC Hb<11g/dL, $15), as well as cost of iron therapy ($61 for established anemia). Sensitivity analyses were performed. RESULTS: Under current market conditions, the incremental cost to diagnose and treat iron deficiency, compared with diagnosing and treating anemia by Hb, was only $22 per patient screened ($440 per case of anemia prevented; number needed to treat = 20). With a 10-year time horizon incorporating risks and costs of neurocognitive delays associated with untreated iron deficiency, the cost of the CHr strategy was $280 per case of anemia prevented. CONCLUSIONS: CHr is an affordable strategy to prevent anemia in infants with possible iron deficiency.
Marcus Shaker; Pamela Jenkins; Christina Ullrich; Carlo Brugnara; Bao Tram Nghiem; Henry Bernstein
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-08-29
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  AIM; IM    
Children's Hospital at Dartmouth, Lebanon, NH, USA.
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MeSH Terms
Anemia, Iron-Deficiency / diagnosis,  economics*,  prevention & control*
Blood Cell Count
Cost of Illness
Cost-Benefit Analysis
Erythrocyte Indices* / physiology
Hemoglobins / analysis*
Markov Chains
Reticulocytes / chemistry*
United States
Reg. No./Substance:

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