| An economic analysis of anemia prevention during infancy. | |
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MedLine Citation:
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PMID: 18760421 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the cost-benefit profile of reticulocyte hemoglobin content (CHr) with hemoglobin (Hb) alone and Hb as a component of the complete blood count (CBC) for detection and treatment of iron deficiency in 9- to 12-month-old infants. STUDY DESIGN: Cohort simulations were used to compare CHr with Hb from a societal perspective. Assumptions included a 9% prevalence of iron deficiency and testing characteristics/costs of CHr, Hb, and CBC (CHr <27.5 pg: sensitivity 83%, specificity 72%, $11; Hb <11 g/dL: sensitivity 26%, specificity 95%, $5; CBC Hb<11g/dL, $15), as well as cost of iron therapy ($61 for established anemia). Sensitivity analyses were performed. RESULTS: Under current market conditions, the incremental cost to diagnose and treat iron deficiency, compared with diagnosing and treating anemia by Hb, was only $22 per patient screened ($440 per case of anemia prevented; number needed to treat = 20). With a 10-year time horizon incorporating risks and costs of neurocognitive delays associated with untreated iron deficiency, the cost of the CHr strategy was $280 per case of anemia prevented. CONCLUSIONS: CHr is an affordable strategy to prevent anemia in infants with possible iron deficiency. |
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Authors:
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Marcus Shaker; Pamela Jenkins; Christina Ullrich; Carlo Brugnara; Bao Tram Nghiem; Henry Bernstein |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-08-29 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 154 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-03 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 44-9 Citation Subset: AIM; IM |
Affiliation:
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Children's Hospital at Dartmouth, Lebanon, NH, USA. marcus.shaker@dartmouth.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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diagnosis,
economics*,
prevention & control* Blood Cell Count Cost of Illness Cost-Benefit Analysis Erythrocyte Indices* / physiology Hemoglobins / analysis* Humans Infant Markov Chains Reticulocytes / chemistry* United States |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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