| An ecdysteroid-induced alteration in the cell cycle of cultured Drosophila cells. | |
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MedLine Citation:
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PMID: 6780197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The addition of physiological concentrations of the arthropod molting hormone 20-hydroxyecdysone results in the cessation of cell division in the Kc cell line of Drosophila melanogaster. Fluorometric mononitoring of the cell cycle reveals that treatment of the cells with hormone for 12 hr causes a G2 arrest. The dose-response curves are in agreement with those obtained for other hormonal effects in both the Kc line and the intact animal. In the continual presence of hormone, cells remain G2-arrested for approximately 100 hr, resuming division by 120 hr. Cells which have responded once to ecdysteroids and subsequently reentered the cell cycle are insensitive to hormonal restimulation. This lack of response has been correlated with, and is probably due to, the loss of ecdysteroid receptors in stimulated cells. |
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Authors:
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B Stevens; C M Alvarez; R Bohman; J D O'Connor |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cell Volume: 22 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-04-13 Completed Date: 1981-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 675-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / drug effects* Cell Line Dose-Response Relationship, Drug Drosophila melanogaster / cytology*, metabolism Ecdysterone / metabolism, pharmacology* Mitosis |
| Chemical | |
Reg. No./Substance:
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5289-74-7/Ecdysterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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