Document Detail


The ease of breathing test tracks clinical changes in cystic fibrosis.
MedLine Citation:
PMID:  22494909     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The EOB is a measure of dyspnea that correlates with CF pulmonary function and exercise tolerance, but has not been shown to track clinical changes. METHODS: The EOB was administered before and after treatment for twelve episodes of exacerbations in eleven pediatric CF subjects. Each subject performed the EOB Sustained Phonation and Single Breath Counting measures before and after treatment both at rest and after exercise. RESULTS: Phonation was significantly better pre-exercise after treatment than initially (Z=-2.20, p=0.028). Phonation post-exercise was longer at follow-up than pre- antibiotics (Z=-1.91, p=0.056). Changes in post-exercise Phonation correlated significantly with changes in FEV1 before and after treatment (R=0.66, p=0.020). CONCLUSIONS: The EOB Sustained Phonation is a validated tool for tracking improvement of pediatric CF patients after antibiotic therapy and has potential as a research tool to gauge efficacy of new therapies.
Authors:
Traci Kazmerski; David M Orenstein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-9
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  -     ISSN:  1873-5010     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Affiliation:
Children's Hospital of Pittsburgh of UPMC, Administrative Office Building, One Children's Hospital Drive, 4401 Penn Ave., Pittsburgh, PA 15224, United States.
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