Document Detail

The early treatment of Parkinson's disease: levodopa, dopamine agonists or both.
MedLine Citation:
PMID:  11008193     Owner:  NLM     Status:  Publisher    
Much has been written about the pharmacologic management of Parkinson's disease (PD) because of an expanding arsenal of antiparkinson drugs and our quest to alter the natural history of disease. Choice of initial therapy may prove fundamental to a treatment strategy that maximizes symptomatic control while minimizing the chances for long-term complications such as motor fluctuations and dyskinesias. Dopamine agonists (DA) have assumed a primary role in the early therapy of PD because of their antiparkinson effectiveness and low propensity to induce fluctuations and dyskinesias. Four available DA in the United States and an array of recent studies supporting their utility in early PD have shaped current PD management. Moreover, DA have neuroprotective properties in vivo. Nevertheless, levodopa remains the most effective drug for symptomatic control in PD. There is conflicting evidence regarding the putative neurotoxicity of levodopa and the mechanisms for levodopa-related motor fluctuations are not entirely known. Clinicians must therefore weigh the available evidence as they initiate therapy in PD. Clearly, both DA and levodopa will remain essential components of the early management of PD.
Related Documents :
19494773 - Akineto-rigid vs. tremor syndromes in parkinsonism.
11747313 - Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in pc12 cells.
20118733 - Potential conditions causing impairment of selective hepatobiliary enhancement of gadob...
Publication Detail:
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  7     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  27-33     Citation Subset:  -    
Parkinson's Disease and Movement Disorders Center, University of Pennsylvania, Philadelphia, PA, USA
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Restless legs syndrome and its treatment by dopamine agonists.
Next Document:  Double blinded evaluation of the effects of pallidal and subthalamic nucleus stimulation on daytime ...