Document Detail


The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia.
MedLine Citation:
PMID:  12648069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Real-time quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR) is increasingly used to monitor responses in chronic myeloid leukaemia (CML). The peripheral blood BCR-ABL/ABL ratio, as assessed by Q-RT-PCR, has been shown to correlate with the contemporary cytogenetic response in patients receiving imatinib (Glivec, Gleevec). We have used Q-RT-PCR to monitor the early molecular response to 4 weeks and 3 months of imatinib therapy, in 47 patients with established CML. After 4 weeks of imatinib therapy, patients whose BCR-ABL/ABL ratio had fallen to less than 50% that of baseline had a significantly higher probability of achieving a major cytogenetic response after 6 months of therapy, when compared with those whose ratio did not fall by this amount (P < 0.001). Similarly, patients whose ratio at 3 months was less than 10% of that at baseline had a significantly higher probability of achieving a major cytogenetic remission at 6 months (P < 0.001). Patients who achieved these falls in their BCR-ABL/ABL ratio at either 4 weeks or 3 months had a superior progression-free survival at a median follow-up of 16.5 months (P = 0.01 and 0.003 respectively). These effects were independent of patient age and disease stage. The occurrence of peripheral blood cytopenias sufficiently severe to interrupt therapy was unrelated to progression-free survival. In conclusion, the data suggest that the early trend in the BCR-ABL/ABL ratio may be clinically useful for the early identification of patients destined to fare poorly on imatinib.
Authors:
Lihui Wang; Kevin Pearson; Julia E Ferguson; Richard E Clark
Related Documents :
14670929 - The prognostic impact of autologous stem cell transplantation in patients with chronic ...
1503099 - Cyclosporine and prednisone therapy for pure red cell aplasia in patients with chronic ...
19811329 - Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: change...
24672769 - Pathologic collision of inverted papilloma with esthesioneuroblastoma.
24468919 - Survival after 131i-labeled lipiodol therapy for hepatocellular carcinoma. a single-cen...
24390779 - Adjuvant radiotherapy and lymph node dissection in pancreatic cancer treated with surge...
15179009 - Clinical implications of minimal residual disease monitoring for stem cell transplantat...
23588459 - Phase angle as a nutritional evaluation tool in all stages of chronic liver disease.
12705989 - Psa bouncing after external beam radiation for prostate cancer with or without hormonal...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  120     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-08-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  990-9     Citation Subset:  IM    
Affiliation:
Department of Haematology, Royal Liverpool University Hospital, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents / therapeutic use*
Disease-Free Survival
Female
Follow-Up Studies
Fusion Proteins, bcr-abl / genetics*
Genetic Markers
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*,  genetics,  mortality
Male
Middle Aged
Piperazines / therapeutic use*
Proto-Oncogene Proteins c-abl / genetics*
Pyrimidines / therapeutic use*
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Fusion Proteins, bcr-abl; 0/Genetic Markers; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib; EC 2.7.10.2/Proto-Oncogene Proteins c-abl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Over-expression of short isoforms of Helios in patients with adult T-cell leukaemia/lymphoma.
Next Document:  Expression of human leucocyte antigens and co-stimulatory molecules on blasts of patients with acute...