| An early decrease in cell proliferation after pentylenetetrazole-induced seizures. | |
| | |
MedLine Citation:
|
PMID: 21907628 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
There are increasing data on the influence of seizures on neurogenesis in the adult brain. However, data on cell proliferation and differentiation during the early stages of kindling are scarce. We have used pentylenetetrazole (PTZ)-induced kindling to investigate the temporal profile of cytogenesis in the germinative zones of adult rat brain. For comparison, we also used a single PTZ-induced generalized tonic-clonic seizure. During kindling development, the density of 5-bromo-2'-deoxyuridine-positive cells demonstrated similar changes in all germinative zones: a dramatic decrease after the first subthreshold PTZ injection, and a gradual increase to the control level following repeated PTZ administration. On the contrary, a single PTZ-induced generalized tonic-clonic seizure was followed by an increase in the number of proliferating cells in both the dentate gyrus and the subventricular zone. These results may indicate the existence of global mechanisms affecting cellular proliferation in adult brain during seizures. Different temporal profiles of neuronal damage and proliferation changes suggest that neurodegeneration is unlikely to be a global proliferation-regulating factor. The data may contribute to better understanding of the initial phase of kindling development and epileptogenesis. |
| | |
Authors:
|
V A Aniol; M Yu Stepanichev; N A Lazareva; N V Gulyaeva |
Related Documents
:
|
10325728 - Rapid onset transverse myelitis in adolescence: implications for pathogenesis and progn... 3694268 - Direct somatosensory projections from the spinal cord to the hypothalamus and telenceph... 21613478 - Phosphorylation of histone h2a.x as an early marker of neuronal endangerment following ... 7609908 - Transcutaneous magnetic stimulation of descending tracts in the cervical spinal cord in... 177738 - The reinnervated motor unit in man. a single fibre emg multielectrode investigation. 14340078 - Movements of radioactive sodium in cerebral-cortex slices in response to electrical sti... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-8 |
Journal Detail:
|
Title: Epilepsy & behavior : E&B Volume: - ISSN: 1525-5069 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adherence to antiepileptic drugs and beliefs about medication among predominantly ethnic minority pa...
Next Document: Temporal lobe epilepsy manifesting as alexia with agraphia for kanji.