Document Detail


The early clinical manifestations of Lyme disease.
MedLine Citation:
PMID:  6859726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lyme disease, caused by a tick-transmitted spirochete, typically begins with a unique skin lesion, erythema chronicum migrans. Of 314 patients with this skin lesion, almost half developed multiple annular secondary lesions; some patients had evanescent red blotches or circles, malar or urticarial rash, conjunctivitis, periorbital edema, or diffuse erythema. Skin manifestations were often accompanied by malaise and fatigue, headache, fever and chills, generalized achiness, and regional lymphadenopathy. In addition, patients sometimes had evidence of meningeal irritation, mild encephalopathy, migratory musculoskeletal pain, hepatitis, generalized lymphadenopathy and splenomegaly, sore throat, nonproductive cough, or testicular swelling. These signs and symptoms were typically intermittent and changing during a period of several weeks. The commonest nonspecific laboratory abnormalities were a high sedimentation rate, an elevated serum IgM level, or an increased aspartate transaminase level. Early Lyme disease can be diagnosed by its dermatologic manifestations, rapidly changing system involvement, and if necessary, by serologic testing.
Authors:
A C Steere; N H Bartenhagen; J E Craft; G J Hutchinson; J H Newman; D W Rahn; L H Sigal; P N Spieler; K S Stenn; S E Malawista
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  99     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abdomen
Adolescent
Adult
Aged
Arthritis, Infectious / diagnosis*
Bone Diseases / etiology
Child
Child, Preschool
Diagnosis, Differential
Erythema / etiology
Female
Humans
Male
Middle Aged
Muscular Diseases / etiology
Nervous System Diseases / etiology
Skin Manifestations
Spirochaetales Infections / diagnosis
Time Factors
Grant Support
ID/Acronym/Agency:
AM-07107/AM/NIADDK NIH HHS; AM-20358/AM/NIADDK NIH HHS; AM-5639/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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