| Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study. | |
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MedLine Citation:
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PMID: 17188055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes. DESIGN: Population-based, cross-sectional study. METHODS: A sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs. RESULTS: After adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8). CONCLUSIONS: These data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations. |
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Authors:
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Andrea Grosso; Thomas H Mosley; Ronald Klein; David J Couper; Gabriella Tikellis; Tien Y Wong; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-08-31 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 143 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-25 Completed Date: 2007-02-08 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 157-9 Citation Subset: AIM; IM |
Affiliation:
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Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrophy Brain / pathology* Brain Diseases / complications*, diagnosis Cross-Sectional Studies Female Humans Macular Degeneration / complications*, diagnosis Magnetic Resonance Imaging* Male Middle Aged Photography Prevalence Retina / pathology* Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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N01 HC 55015/HC/NHLBI NIH HHS; N01 HC 55016/HC/NHLBI NIH HHS; N01 HC 55018/HC/NHLBI NIH HHS; N01 HC 55019/HC/NHLBI NIH HHS; N01 HC 55020/HC/NHLBI NIH HHS; N01 HC 55021/HC/NHLBI NIH HHS; N01 HC 55022/HC/NHLBI NIH HHS |
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