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eNOS Tag SNP Haplotypes in Hypertensive Disorders of Pregnancy.
MedLine Citation:
PMID:  23062210     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Haplotypes formed by polymorphisms (T-786C, rs2070744; a variable number of tandem repeats in intron 4, and Glu298Asp, rs1799983) of the eNOS gene were associated previously with gestational hypertension (GH) and preeclampsia (PE). However, no study has explored the Tag SNPs rs743506 and rs7830 in these disorders. The aim of the current study was to compare the distribution of the genotypes and haplotypes formed by the five eNOS polymorphisms mentioned among healthy pregnant (HP, n=122), GH (n=138), and PE (n=157). The haplotype formed by "C b G G C" was more frequent in HP compared to GH and PE (p=0.0071), which is supported by previous findings that demonstrated the association of the combination "C b G" with a higher level of nitrite (NO marker). Our results suggest a protective effect of the haplotype "C b G G C" against the development of hypertensive disorders of pregnancy.
Authors:
Ludmila Muniz; Marcelo R Luizon; Ana C T Palei; Riccardo Lacchini; Geraldo Duarte; Ricardo C Cavalli; Jose E Tanus-Santos; Valeria C Sandrim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  DNA and cell biology     Volume:  -     ISSN:  1557-7430     ISO Abbreviation:  DNA Cell Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004522     Medline TA:  DNA Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Center of Postgraduation and Research - Santa Casa of Belo Horizonte, Belo Horizonte, Brazil .
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