| A dystonic syndrome associated with anti-basal ganglia antibodies. | |
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MedLine Citation:
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PMID: 15146015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders (usually tics and chorea) and psychiatric disturbance in children. This report describes five adult and adolescent patients (one male, four females; mean age of onset, 16 years (range, 13-35)) who presented subacutely with a clinical syndrome dominated by dystonia and had ABGA binding to antigens of similar molecular weights to those seen in Sydenham's chorea. Three patients had a clear history of respiratory infection before the onset of their symptoms. Three patients received immunosuppressive treatment, with three showing a notable reduction in symptoms. It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA. |
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Authors:
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M J Edwards; R C Dale; A J Church; G Giovannoni; K P Bhatia |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 75 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-17 Completed Date: 2004-06-11 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 914-6 Citation Subset: IM |
Affiliation:
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Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Autoantibodies / analysis*, immunology Autoimmune Diseases of the Nervous System / immunology*, psychology, therapy Basal Ganglia / immunology* Basal Ganglia Diseases / immunology Chorea / immunology Dystonic Disorders / immunology*, psychology, therapy Female Humans Immunoglobulins, Intravenous / therapeutic use Immunosuppression Male Middle Aged Molecular Mimicry / immunology Respiratory Tract Infections / immunology Streptococcal Infections / immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulins, Intravenous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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