Document Detail

A dystonic syndrome associated with anti-basal ganglia antibodies.
MedLine Citation:
PMID:  15146015     Owner:  NLM     Status:  MEDLINE    
Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders (usually tics and chorea) and psychiatric disturbance in children. This report describes five adult and adolescent patients (one male, four females; mean age of onset, 16 years (range, 13-35)) who presented subacutely with a clinical syndrome dominated by dystonia and had ABGA binding to antigens of similar molecular weights to those seen in Sydenham's chorea. Three patients had a clear history of respiratory infection before the onset of their symptoms. Three patients received immunosuppressive treatment, with three showing a notable reduction in symptoms. It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA.
M J Edwards; R C Dale; A J Church; G Giovannoni; K P Bhatia
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  75     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-17     Completed Date:  2004-06-11     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  914-6     Citation Subset:  IM    
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
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MeSH Terms
Autoantibodies / analysis*,  immunology
Autoimmune Diseases of the Nervous System / immunology*,  psychology,  therapy
Basal Ganglia / immunology*
Basal Ganglia Diseases / immunology
Chorea / immunology
Dystonic Disorders / immunology*,  psychology,  therapy
Immunoglobulins, Intravenous / therapeutic use
Middle Aged
Molecular Mimicry / immunology
Respiratory Tract Infections / immunology
Streptococcal Infections / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulins, Intravenous

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