Document Detail

The dystonias.
MedLine Citation:
PMID:  1623256     Owner:  NLM     Status:  MEDLINE    
The various dystonias have been found in at least five different hereditary backgrounds. The gene responsible for one of the dystonias, idiopathic torsion dystonia (ITD), lies on chromosome 9q32-34, with flanking markers now 1-2 cM apart. Magnetic resonance imaging and computerized tomography (CT) abnormalities in the basal ganglia, especially in the putamen, are found in many secondary dystonias. Botulinum toxin therapy is proving very useful in the treatment of focal dystonias.
C H Markham
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology and neurosurgery     Volume:  5     ISSN:  0951-7383     ISO Abbreviation:  Curr Opin Neurol Neurosurg     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-12     Completed Date:  1992-08-12     Revised Date:  2013-03-26    
Medline Journal Info:
Nlm Unique ID:  8809879     Medline TA:  Curr Opin Neurol Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-7     Citation Subset:  IM; S    
Department of Neurology, UCLA School of Medicine.
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MeSH Terms
Basal Ganglia / abnormalities,  pathology,  physiopathology
Botulinum Toxins / administration & dosage,  therapeutic use*
Chromosomes, Human, Pair 9
Disease Models, Animal
Dystonia / classification*,  drug therapy,  etiology*,  physiopathology
Dystonia Musculorum Deformans / drug therapy,  genetics,  physiopathology
Injections, Intramuscular
Levodopa / therapeutic use*
Magnetic Resonance Imaging
Muscle Contraction / physiology
Muscles / physiology,  physiopathology
Neurologic Examination / drug effects
Tomography, Emission-Computed
Tomography, X-Ray Computed
Reg. No./Substance:
0/Levodopa; EC Toxins

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