Document Detail


A dysbalanced immune system in cryptogenic Lennox-Gastaut syndrome.
MedLine Citation:
PMID:  7863268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In children with cryptogenic Lennox-Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced-triggered as well as functionally impaired-immune system, has also been described in an auto-immune disease like systemic lupus erythaematodes in humans, and in genetically epilepsy-prone rats. The interactions between the immune system and the nervous system in Lennox-Gastaut syndrome will be discussed.
Authors:
B G van Engelen; C M Weemaes; W O Renier; J A Bakkeren; G F Borm; P F Strengers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  41     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-17     Completed Date:  1995-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Epilepsy, Absence / immunology*
Female
Hemocyanin / immunology
Humans
Immunoglobulin A / blood
Immunoglobulin G / blood
Immunoglobulin Isotypes / blood*
Immunoglobulin M / blood
Infant
Male
Syndrome
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 0/Immunoglobulin M; 9013-72-3/Hemocyanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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