Document Detail


The dynamics of vein graft remodeling induced by hemodynamic forces: a mathematical model.
MedLine Citation:
PMID:  21691849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although vein bypass grafting is one of the primary options for the treatment of arterial occlusive disease and provides satisfactory results at an early stage of the treatment, the patency is limited to a few months in many patients. When the vein is implanted in the arterial system, it adapts to the high flow rate and high pressure of the arterial environment by changing the sizes of its layers, and this remodeling is believed to be a precursor of future graft failure. Hemodynamic forces, such as wall shear stress (WSS) and wall tension, have been recognized as major factors impacting vein graft remodeling. Although a wide range of experimental evidence relating hemodynamic forces to vein graft remodeling has been reported, a comprehensive mathematical model describing the relationship among WSS, wall tension, and the structural adaptation of each individual layer of the vein graft wall is lacking. The current manuscript presents a comprehensive and robust framework for treating the complex interaction between the WSS, wall tension, and the structural adaptation of each individual layer of the vein graft wall. We modeled the intimal and medial area and the radius of external elastic lamina, which in combination dictate luminal narrowing and the propensity for graft occlusion. Central to our model is a logistic relationship between independent and dependent variables to describe the initial increase and later decrease in the growth rate. The detailed understanding of the temporal changes in vein graft morphology that can be extracted from the current model is critical in identifying the dominant contributions to vein graft failure and the further development of strategies to improve their longevity.
Authors:
Minki Hwang; Scott A Berceli; Marc Garbey; Nam Ho Kim; Roger Tran-Son-Tay
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-21
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  11     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-06-22     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  411-23     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanical Phenomena
Computer Simulation
Hemodynamics
Models, Statistical
Models, Theoretical
Rabbits
Software
Stress, Mechanical
Tensile Strength
Time Factors
Tunica Intima / pathology
Tunica Media / pathology
Veins / pathology*,  transplantation
Grant Support
ID/Acronym/Agency:
R01 HL095508/HL/NHLBI NIH HHS; R01-HL095508-01/HL/NHLBI NIH HHS

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