| The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum. | |
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MedLine Citation:
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PMID: 19864183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. Investigating the dynamics of resistance against these antimalarial drugs will lead to approaches for addressing the problem of resistance in malarial parasites that are solidly based in evolutionary genetics and population biology. In this article, we discuss current developments in population biology modeling and evolutionary genetics. Despite great advancements achieved in the past decade, understanding the complex dynamics of mutations conferring drug resistance in P. falciparum requires approaches that consider the parasite population structure among other demographic processes. |
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Authors:
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Ananias A Escalante; David L Smith; Yuseob Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-10-26 |
Journal Detail:
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Title: Trends in parasitology Volume: 25 ISSN: 1471-5007 ISO Abbreviation: Trends Parasitol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-02-23 Revised Date: 2011-05-25 |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: England |
Other Details:
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Languages: eng Pagination: 557-63 Citation Subset: IM |
Affiliation:
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School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ 85287-4501, USA. Ananias.Escalante@asu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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pharmacology*,
therapeutic use Drug Resistance / genetics* Geography Humans Malaria, Falciparum / drug therapy, transmission Models, Biological Mutation / genetics* Plasmodium falciparum / drug effects*, genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM084320-02/GM/NIGMS NIH HHS; R01GM084320/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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