Document Detail


The dynamics of the mitochondrial organelle as a potential therapeutic target.
MedLine Citation:
PMID:  23093069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondria play a central role in cell fate after stressors such as ischemic brain injury. The convergence of intracellular signaling pathways on mitochondria and their release of critical factors are now recognized as a default conduit to cell death or survival. Besides the individual processes that converge on or emanate from mitochondria, a mitochondrial organellar response to changes in the cellular environment has recently been described. Whereas mitochondria have previously been perceived as a major center for cellular signaling, one can postulate that the organelle's dynamics themselves affect cell survival. This brief perspective review puts forward the concept that disruptions in mitochondrial dynamics--biogenesis, clearance, and fission/fusion events--may underlie neural diseases and thus could be targeted as neuroprotective strategies in the context of ischemic injury. To do so, we present a general overview of the current understanding of mitochondrial dynamics and regulation. We then review emerging studies that correlate mitochondrial biogenesis, mitophagy, and fission/fusion events with neurologic disease and recovery. An overview of the system as it is currently understood is presented, and current assessment strategies and their limitations are discussed.
Authors:
R Anne Stetler; Rehana K Leak; Yanqin Gao; Jun Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-24
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  33     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-02-21     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / drug therapy,  genetics,  metabolism,  pathology*
Humans
Membrane Fusion / drug effects
Mitochondria / drug effects*,  genetics,  metabolism,  ultrastructure*
Mitochondrial Degradation / drug effects
Mitochondrial Membranes / drug effects,  metabolism,  ultrasonography
Mitochondrial Proteins / genetics,  metabolism
Neurodegenerative Diseases / drug therapy,  genetics,  metabolism,  pathology*
Neuroprotective Agents / therapeutic use
Grant Support
ID/Acronym/Agency:
NS36736/NS/NINDS NIH HHS; NS43802/NS/NINDS NIH HHS; NS45048/NS/NINDS NIH HHS; NS56118/NS/NINDS NIH HHS; R01 NS045048/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Mitochondrial Proteins; 0/Neuroprotective Agents
Comments/Corrections

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