Document Detail

A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development.
MedLine Citation:
PMID:  18976913     Owner:  NLM     Status:  MEDLINE    
Unlike animals that produce gametes upon differentiation of meiotic products, plants develop haploid male and female gametophytes that differentiate gametes such as sperm, egg and central cells, and accessory cells [1, 2]. Both gametophytes participate in double fertilization and give rise to the next sporophytic generation. Little is known about the function of cell-cycle genes in differentiation and development of gametophytes and in reproduction [1, 2]. RETINOBLASTOMA RELATED (RBR) is a plant homolog of the tumor suppressor Retinoblastoma (pRb), which is primarily known as negative regulator of the cell cycle [3]. We show that RBR is required for cell differentiation of male and female gametophytes in Arabidopsis and that loss of RBR perturbs expression levels of the evolutionarily ancient Polycomb Repressive Complex 2 (PRC2) subunits and their modifiers encoding PRC2 subunits or DNA METHYLTRANSFERASE 1 (MET1) [4-6], exemplifying convergent evolution involving the RBR-PRC2-MET1 regulatory pathways. In addition, RBR binds MET1, and maintenance of heterochromatin in central cells, a mechanism that is likely mediated by MET1[7, 8], is impaired in the absence of RBR. Surprisingly, PRC2-specific H3K27-trimethylation activity represses paternal RBR allele, suggesting a functional role for a dynamic and reciprocal RBR-PRC2 regulatory circuit in cellular differentiation and reproductive development.
Amal J Johnston; Elena Matveeva; Olga Kirioukhova; Ueli Grossniklaus; Wilhelm Gruissem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-30
Journal Detail:
Title:  Current biology : CB     Volume:  18     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1680-6     Citation Subset:  IM    
Plant Biotechnology, Institute of Plant Sciences & Zurich-Basel Plant Science Center, ETH Zurich, Universitätstrasse 2, CH-8092 Zurich, Switzerland.
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MeSH Terms
Arabidopsis / genetics,  growth & development*,  metabolism
Arabidopsis Proteins / metabolism*
Cell Differentiation
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Heterochromatin / metabolism
Repressor Proteins / metabolism*
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Heterochromatin; 0/RBR1 protein, Arabidopsis; 0/Repressor Proteins; 0/polycomb protein, plant

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