Document Detail


A dynamic reciprocal RBR-PRC2 regulatory circuit controls Arabidopsis gametophyte development.
MedLine Citation:
PMID:  18976913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unlike animals that produce gametes upon differentiation of meiotic products, plants develop haploid male and female gametophytes that differentiate gametes such as sperm, egg and central cells, and accessory cells [1, 2]. Both gametophytes participate in double fertilization and give rise to the next sporophytic generation. Little is known about the function of cell-cycle genes in differentiation and development of gametophytes and in reproduction [1, 2]. RETINOBLASTOMA RELATED (RBR) is a plant homolog of the tumor suppressor Retinoblastoma (pRb), which is primarily known as negative regulator of the cell cycle [3]. We show that RBR is required for cell differentiation of male and female gametophytes in Arabidopsis and that loss of RBR perturbs expression levels of the evolutionarily ancient Polycomb Repressive Complex 2 (PRC2) subunits and their modifiers encoding PRC2 subunits or DNA METHYLTRANSFERASE 1 (MET1) [4-6], exemplifying convergent evolution involving the RBR-PRC2-MET1 regulatory pathways. In addition, RBR binds MET1, and maintenance of heterochromatin in central cells, a mechanism that is likely mediated by MET1[7, 8], is impaired in the absence of RBR. Surprisingly, PRC2-specific H3K27-trimethylation activity represses paternal RBR allele, suggesting a functional role for a dynamic and reciprocal RBR-PRC2 regulatory circuit in cellular differentiation and reproductive development.
Authors:
Amal J Johnston; Elena Matveeva; Olga Kirioukhova; Ueli Grossniklaus; Wilhelm Gruissem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-30
Journal Detail:
Title:  Current biology : CB     Volume:  18     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1680-6     Citation Subset:  IM    
Affiliation:
Plant Biotechnology, Institute of Plant Sciences & Zurich-Basel Plant Science Center, ETH Zurich, Universitätstrasse 2, CH-8092 Zurich, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics,  growth & development*,  metabolism
Arabidopsis Proteins / metabolism*
Cell Differentiation
Gene Expression Regulation, Developmental
Gene Expression Regulation, Plant
Heterochromatin / metabolism
Repressor Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Heterochromatin; 0/RBR1 protein, Arabidopsis; 0/Repressor Proteins; 0/polycomb protein, plant

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