Document Detail

The dynamic performances of DDTs in the environment and Japanese exposure to them: a historical perspective after the ban.
MedLine Citation:
PMID:  12022674     Owner:  NLM     Status:  MEDLINE    
The fugacity model for evaluating DDTs dynamic performances in the environment was combined with the dietary exposure evaluation model, including the contribution of imported food, to develop the macroscopic mathematical model relating DDTs in the environment with the health risks of the reference Japanese. The model validity was examined by comparing the simulated DDTs concentrations in environmental media, various kinds of food, and dietary intake with those observed. Numerical simulations were done for the past half and future of one century to evaluate the effect of the DDTs usage prohibition in 1970 in Japan. The major results obtained under the limits considered are as follows. The DDTs concentrations in environmental media, various kinds of foods, and the dietary intake showed the steady exponential decrease after the DDTs usage prohibition in 1970. The DDE/DDTs ratio is larger in the higher position in an ecological system, and increased steadily with time. The critical exposure of DDTs occurred through animal product intake until 1960; after 1990 marine product intake caused the most exposure. The estimated DDTs intake was evaluated to be less than the PTDI and RfD. The annual excess cancer induction risk due to the annual dietary intake of DDTs was the largest at the level of (0.5 - 2.0) x 10(-6) (1/yr) in the early 1970s. The effect of the DDT usage prohibition on dietary exposure reduction was expected to appear after about 20 years. The life-span excess cancer induction risk was conservatively estimated to be larger than 10(-5) (1/lifespan) for the reference Japanese who were born before 1970. The DDTs usage prohibition in 1970 was effective to reduce the life-span cancer risk under the 10(-5) level.
Shinsuke Morisawa; Atsushi Kato; Minoru Yoneda; Yoko Shimada
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Risk analysis : an official publication of the Society for Risk Analysis     Volume:  22     ISSN:  0272-4332     ISO Abbreviation:  Risk Anal.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-22     Completed Date:  2002-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109978     Medline TA:  Risk Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-63     Citation Subset:  IM    
Department of Global Environmental Engineering, Graduate School of Engineering, Kyoto University.
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MeSH Terms
DDT / history*,  toxicity
Environmental Pollutants / history*,  toxicity
Food Contamination / prevention & control
History, 20th Century
Models, Biological
Neoplasms / etiology,  history
Public Health / history
Risk Assessment / history
Reg. No./Substance:
0/Environmental Pollutants; 50-29-3/DDT

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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