Document Detail


The dynamic nature of ventricular tachycardia initiation.
MedLine Citation:
PMID:  21076714     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Initiation of ventricular tachycardia (VT) or ventricular fibrillation (VF) requires heterogeneity of the substrate. This heterogeneity has a stable/fixed component (structural or functional) and a dynamic component. The latter explains the random and sudden destabilization of the substrate and the initiation of VT or VF by a ventricular extra stimulus trigger. The main mechanisms of dynamic heterogeneity are discussed at the cellular level (action potential duration alternans and restitution and intracellular calcium cycling instability) and at the tissue level (conduction velocity restitution and concordant and discordant alternans). Better knowledge of dynamic factors in arrhythmogenesis has an overwhelming impact on both predicting malignant arrhythmias and changing the antiarrhythmic drug paradigm from suppressing triggers to modifying dynamic instability factors.
Authors:
G A Dan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs of today (Barcelona, Spain : 1998)     Volume:  46     ISSN:  1699-3993     ISO Abbreviation:  Drugs Today     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160518     Medline TA:  Drugs Today (Barc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-83     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
Affiliation:
Carol Davila University of Medicine, Colentina University Hospital, Bucharest, Romania. andrei.dan@imail.softnet.ro
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