| A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source. | |
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MedLine Citation:
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PMID: 19321922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current commercial micro-CT scanners have the capability of imaging objects ex vivo with high spatial resolution, but performing in vivo micro-CT on free-breathing small animals is still challenging because their physiological motions are non-periodic and much faster than those of humans. In this paper, we present a prototype physiologically gated micro-computed tomography (micro-CT) scanner based on a carbon nanotube field emission micro-focus x-ray source. The novel x-ray source allows x-ray pulses and imaging sequences to be readily synchronized and gated to non-periodic physiological signals from small animals. The system performance is evaluated using phantoms and sacrificed and anesthetized mice. Prospective respiratory-gated micro-CT images of anesthetized free-breathing mice were collected using this scanner at 50 ms temporal resolution and 6.2 lp mm(-1) at 10% system MTF. The high spatial and temporal resolutions of the micro-CT scanner make it well suited for high-resolution imaging of free-breathing small animals. |
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Authors:
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G Cao; Y Z Lee; R Peng; Z Liu; R Rajaram; X Calderon-Colon; L An; P Wang; T Phan; S Sultana; D S Lalush; J P Lu; O Zhou |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-03-25 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 54 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 2323-40 Citation Subset: IM |
Affiliation:
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Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599, USA. gcao@physics.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Feasibility Studies Linear Models Mice Nanotubes, Carbon* Prospective Studies Radiation Dosage Respiration Respiratory-Gated Imaging Techniques Time Factors X-Ray Microtomography / instrumentation* |
| Grant Support | |
ID/Acronym/Agency:
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4R33ER004204-01//PHS HHS; U54CA119343/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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