Document Detail


The dualistic role of vitamin D in vascular calcifications.
MedLine Citation:
PMID:  20962746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D is a multifunctional hormone that can affect many essential biological functions, ranging from the immune regulation to mineral ion metabolism. A close association between altered activity of vitamin D and vascular calcification has been reported in various human diseases, including in patients with atherosclerosis, osteoporosis, and chronic kidney disease (CKD). Vascular calcification is a progressive disorder and is a major determinant of morbidity and mortality of the affected patients. Experimental studies have shown that excessive vitamin D activities can induce vascular calcification, and such vascular pathology can be reversed by reducing vitamin D activities. The human relevance of these experimental studies is not clear, as vitamin D toxicity is relatively rare in the general population. Contrary to the relationship between vitamin D and vascular calcification, in experimental uremic models, low levels of vitamin D were shown to be associated with extensive vascular calcification, a phenomenon that is very similar to the vascular pathology seen in patients with CKD. The current treatment approach of providing vitamin D analogs to patients with CKD often poses a dilemma, as studies linked vitamin D treatment to subsequent vascular calcification. Recent genetic studies, however, have shown that vascular calcification can be prevented by reducing serum phosphate levels, even in the presence of extremely high serum 1,25-dihydroxyvitamin D and calcium levels. This article will briefly summarize the dual effects of vitamin D in vascular calcification and will provide evidence of vitamin D-dependent and -independent vascular calcification.
Authors:
M Shawkat Razzaque
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-10-20
Journal Detail:
Title:  Kidney international     Volume:  79     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-15     Completed Date:  2011-07-07     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  708-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcinosis / etiology,  metabolism*,  prevention & control
Calcium / metabolism
Humans
Kidney / metabolism
Phosphates / metabolism
Receptors, Calcitriol / metabolism
Signal Transduction
Vascular Diseases / etiology,  metabolism*,  prevention & control
Vitamin D / adverse effects,  metabolism*,  therapeutic use
Grant Support
ID/Acronym/Agency:
R01 DK077276/DK/NIDDK NIH HHS; R01 DK077276-04/DK/NIDDK NIH HHS; R01-DK077276/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Phosphates; 0/Receptors, Calcitriol; 1406-16-2/Vitamin D; SY7Q814VUP/Calcium
Comments/Corrections

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