| A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells. | |
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MedLine Citation:
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PMID: 15653949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cloaca serves as a common opening to the urinary and digestive systems. In most mammals, the cloaca is present only during embryogenesis, after which it undergoes a series of septation events leading to the formation of the anal canal and parts of the urogenital tract. During embryogenesis it is surrounded by skeletal muscle. The origin and the mechanisms regulating the development of these muscles have never been determined. Here, we show that the cloacal muscles of the chick originate from somites 30-34, which overlap the domain that gives rise to leg muscles (somites 26-33). Using molecular and cell labelling protocols, we have determined the aetiology of cloacal muscles. Surprisingly, we found that chick cloacal myoblasts first migrate into the developing leg bud and then extend out of the ventral muscle mass towards the cloacal tubercle. The development of homologous cloacal/perineal muscles was also examined in the mouse. Concordant with the results in birds, we found that perineal muscles in mammals also develop from the ventral muscle mass of the hindlimb. We provide genetic evidence that the perineal muscles are migratory, like limb muscles, by showing that they are absent in metd/d mutants. Using experimental embryological procedures (in chick) and genetic models (in chick and mouse), we show that the development of the cloacal musculature is dependent on proximal leg field formation. Thus, we have discovered a novel developmental mechanism in vertebrates whereby muscle cells first migrate from axially located somites to the pelvic limb, then extend towards the midline and only then differentiate into the single cloacal/perineal muscles. |
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Authors:
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Petr Valasek; Darrell J R Evans; Flavio Maina; Milos Grim; Ketan Patel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 132 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 447-58 Citation Subset: IM |
Affiliation:
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Veterinary Basic Sciences, Royal Veterinary College, London NW1 0TU, UK. valasekpetr@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement Chick Embryo Cloaca / anatomy & histology, cytology*, embryology, metabolism Embryo, Nonmammalian / cytology, embryology Hindlimb / cytology*, embryology*, metabolism Homeodomain Proteins / genetics, metabolism Mice Mice, Knockout Muscle Cells / cytology* Muscle Proteins / genetics, metabolism Muscle, Skeletal / anatomy & histology, cytology*, embryology*, metabolism Quail / embryology, metabolism Somites / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Lbx1h protein, mouse; 0/Meox2 protein, mouse; 0/Muscle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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