Document Detail

A dual expression of cytokeratin and neurofilaments in bronchial carcinoid cells.
MedLine Citation:
PMID:  2580799     Owner:  NLM     Status:  MEDLINE    
Intermediate filaments (IF) are ubiquitous cytoplasmic structures which, by virtue of their cell- and tissue-type-specific characteristics, are widely used as markers of tissue derivation and as differential diagnostic aids in surgical pathology. In contradistinction to other IFs, vimentin filaments, characteristic of mesenchymal cells, may be co-expressed with other cell-type specific IFs--cytokeratin filaments, desmin filaments, glial filaments and neurofilaments--in some tumor cells, embryonic cells, and cells in vitro. In this study we describe a novel type of IF co-expression which does not involve vimentin-filaments, viz. the presence of both cytokeratin filaments and neurofilaments in human bronchial carcinoid tumor cells.
V P Lehto; M Miettinen; I Virtanen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  35     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-05     Completed Date:  1985-06-05     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
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MeSH Terms
Bronchial Neoplasms / metabolism*
Carcinoid Tumor / metabolism*
Cytoskeleton / metabolism*
Electrophoresis, Polyacrylamide Gel
Fluorescent Antibody Technique
Frozen Sections
Keratins / metabolism*
Microscopy, Fluorescence
Peptides / analysis
Reg. No./Substance:
0/Peptides; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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