Document Detail

Anxiety/aggression--driven depression. A paradigm of functionalization and verticalization of psychiatric diagnosis.
MedLine Citation:
PMID:  11383984     Owner:  NLM     Status:  MEDLINE    
A new subtype of depression is proposed, named: anxiety/aggression-driven depression. The psychopathological, psychopharmacological and biochemical evidence on which this construct is based, is being discussed. Selective postsynaptic 5-HT1A agonists together with CRH and/or cortisol antagonists are hypothesized to be a specific biological treatment for this depression type, in conjunction with psychological interventions to raise the stressor-threshold and to increase coping skills. The development of this depression construct has been contingent on the introduction of two new diagnostic procedures, called functionalization and verticalization of psychiatric diagnosis. These procedures are explained and it is stressed that they are essential to psychiatric diagnosing, in order to put this process on a scientific footing.
H M Van Praag
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  25     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  893-924     Citation Subset:  IM    
Department of Psychiatry and Neuropsychology, Academic Hospital, Brain and Behavior Research Institute, Maastricht University, The Netherlands.
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MeSH Terms
Aggression / psychology*
Anxiety / complications*,  metabolism,  psychology*
Depressive Disorder / etiology*,  metabolism,  psychology*

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