Document Detail

ADF/cofilin-driven actin dynamics in early events of Leishmania cell division.
MedLine Citation:
PMID:  20460437     Owner:  NLM     Status:  MEDLINE    
ADF/cofilin is an actin-dynamics-regulating protein that is required for several actin-based cellular processes such as cell motility and cytokinesis. A homologue of this protein has recently been identified in the protozoan parasite Leishmania, which has been shown to be essentially required in flagellum assembly and cell motility. However, the role of this protein in cytokinesis remains largely unknown. We show here that deletion of the gene encoding ADF/cofilin in these organisms results in several aberrations in the process of cell division. These aberrations include delay in basal body and kinetoplast separation, cleavage furrow progression and flagellar pocket division. In addition to these changes, the intracellular trafficking and actin dynamics are also adversely affected. All these abnormalities are, however, reversed by episomal complementation. Together, these results indicate that actin dynamics regulates early events in Leishmania cell division.
T V Satish Tammana; Amogh A Sahasrabuddhe; Virendra K Bajpai; Chhitar M Gupta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-11
Journal Detail:
Title:  Journal of cell science     Volume:  123     ISSN:  1477-9137     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1894-901     Citation Subset:  IM    
Division of Molecular and Structural Biology, Central Drug Research Institute, M.G. Marg, Lucknow 226001, India.
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MeSH Terms
Actin Depolymerizing Factors / genetics,  immunology,  metabolism*
Actins / immunology,  metabolism*
Antigens, Protozoan / immunology,  metabolism*
Cells, Cultured
Cytokinesis / genetics
Cytoskeleton / metabolism
DNA, Kinetoplast / genetics*
Fluorescent Antibody Technique
Leishmania / physiology*
Microscopy, Electron
Organisms, Genetically Modified
Protein Multimerization / genetics
Protein Transport / genetics
Sequence Deletion / genetics
Reg. No./Substance:
0/Actin Depolymerizing Factors; 0/Actins; 0/Antigens, Protozoan; 0/DNA, Kinetoplast

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