| ADF/cofilin-driven actin dynamics in early events of Leishmania cell division. | |
| | |
MedLine Citation:
|
PMID: 20460437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
ADF/cofilin is an actin-dynamics-regulating protein that is required for several actin-based cellular processes such as cell motility and cytokinesis. A homologue of this protein has recently been identified in the protozoan parasite Leishmania, which has been shown to be essentially required in flagellum assembly and cell motility. However, the role of this protein in cytokinesis remains largely unknown. We show here that deletion of the gene encoding ADF/cofilin in these organisms results in several aberrations in the process of cell division. These aberrations include delay in basal body and kinetoplast separation, cleavage furrow progression and flagellar pocket division. In addition to these changes, the intracellular trafficking and actin dynamics are also adversely affected. All these abnormalities are, however, reversed by episomal complementation. Together, these results indicate that actin dynamics regulates early events in Leishmania cell division. |
| | |
Authors:
|
T V Satish Tammana; Amogh A Sahasrabuddhe; Virendra K Bajpai; Chhitar M Gupta |
Related Documents
:
|
19638477 - Helical growth of the arabidopsis mutant tortifolia2 does not depend on cell division p... 933087 - Effects of actinomycin d on generation time and morphogenesis in paramecium. 20502677 - Integration of light signals by the retinoblastoma pathway in the control of s phase en... 16662317 - Genome expression during normal leaf development : i. cellular and chloroplast numbers ... 2676187 - Flow cytometric correlation of the c-myc oncoprotein and cell cycle kinetics of hl60 le... 4031987 - Activation of dorsal horn cells by ventral root stimulation in the cat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-11 |
Journal Detail:
|
Title: Journal of cell science Volume: 123 ISSN: 1477-9137 ISO Abbreviation: J. Cell. Sci. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-20 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
|
Languages: eng Pagination: 1894-901 Citation Subset: IM |
Affiliation:
|
Division of Molecular and Structural Biology, Central Drug Research Institute, M.G. Marg, Lucknow 226001, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actin Depolymerizing Factors
/
genetics,
immunology,
metabolism* Actins / immunology, metabolism* Antigens, Protozoan / immunology, metabolism* Cells, Cultured Cytokinesis / genetics Cytoskeleton / metabolism DNA, Kinetoplast / genetics* Fluorescent Antibody Technique Leishmania / physiology* Microscopy, Electron Organisms, Genetically Modified Protein Multimerization / genetics Protein Transport / genetics Sequence Deletion / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Actin Depolymerizing Factors; 0/Actins; 0/Antigens, Protozoan; 0/DNA, Kinetoplast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bre1p-mediated histone H2B ubiquitylation regulates apoptosis in Saccharomyces cerevisiae.
Next Document: Claudin-2, a component of the tight junction, forms a paracellular water channel.