Document Detail


The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction.
MedLine Citation:
PMID:  23007187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The growing rates of obesity have prompted comparisons between the uncontrolled intake of food and drugs; however, an evaluation of the equivalence of food- and drug-related behaviors requires a thorough understanding of the underlying neural circuits driving each behavior. Although it has been attractive to borrow neurobiological concepts from addiction to explore compulsive food seeking, a more integrated model is needed to understand how food and drugs differ in their ability to drive behavior. In this Review, we will examine the commonalities and differences in the systems-level and behavioral responses to food and to drugs of abuse, with the goal of identifying areas of research that would address gaps in our understanding and ultimately identify new treatments for obesity or drug addiction.
Authors:
Ralph J DiLeone; Jane R Taylor; Marina R Picciotto
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-09-25
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-25     Completed Date:  2012-12-14     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1330-5     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Addictive / physiopathology*
Brain / physiology,  physiopathology
Drive*
Eating / physiology*
Food
Models, Neurological
Neuropeptides / physiology
Reward*
Substance-Related Disorders / physiopathology*
Grant Support
ID/Acronym/Agency:
DA011017/DA/NIDA NIH HHS; DA014241/DA/NIDA NIH HHS; DA015222/DA/NIDA NIH HHS; DA15425/DA/NIDA NIH HHS; DK076964/DK/NIDDK NIH HHS; R01 DA011717/DA/NIDA NIH HHS; R01 DA014241/DA/NIDA NIH HHS; R01 DA015222/DA/NIDA NIH HHS; R01 DA015425/DA/NIDA NIH HHS; R01 DK076964/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Neuropeptides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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