| The double whammy of endogenous insulin antibodies in non-diabetic subjects. | |
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MedLine Citation:
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PMID: 18324904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of high affinity/avidity endogenous insulin antibodies in significant amounts in non-diabetic individuals could uniquely be a double whammy. Clinically it could trigger pathology, namely hypoglycaemia, and analytically it could cause erroneous and potentially misleading results (i.e., falsely high or falsely low) in the key biochemical parameters essential in the differential diagnosis of this pathology, namely serum insulin, proinsulin and even C-peptide. The purpose of this paper is to highlight the clinical and analytical sequelae of endogenous insulin antibodies in (a) delaying or even confusing the differential diagnosis of unexpected/unexplained hypoglycaemia, and (b) interfering in some immunoassays of pancreatic hormones (commercial or in-house). |
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Authors:
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Adel A A Ismail |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 46 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-03-07 Completed Date: 2008-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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adelaaismail@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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immunology* Diabetes Mellitus / immunology Half-Life Humans Insulin / blood, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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