| "HIT on Trousseau" double trouble: acquired coagulopathy with femoral artery thrombosis. | |
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MedLine Citation:
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PMID: 18690597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trousseau Syndrome is a paraneoplastic procoagulant phenomenon. Heparin-induced thrombocytopenia (HIT) is a rare complication of anticoagulation with heparin. To our knowledge, the coincidence of the two has not been reported so far. We report a case of an acute thrombosis of the left femoral artery and distal leg arteries in a patient with an otherwise normal cardiovascular status. Endovascular revascularization attempts using mechanical rotational thrombectomy catheter, aspiration and local thrombolysis were unsuccessful. Progressive coagulation along the intra-arterial catheter was seen. Surgical thrombectomy of the femoral-pedal axis was successful, but the patient developed an immune-mediated HIT postoperatively. An adenocarcinoma of the colon was the likely cause for the initial arterial thrombosis, and probably adversely affected endovascular revascularization attempts. Subsequent HIT with microvascular thrombosis worsened ischemic damage leading to a below knee-amputation, despite patent large vessels. Compared to venous thrombosis, arterial thrombosis is a rare manifestation of Trousseau syndrome. The coincidence of it with HIT is even rarer. There may be a causal relationship between the two. |
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Authors:
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C Warncke; L Alberio; H Savolainen; R von Allmen; I Baumgartner; M Husmann |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: VASA. Zeitschrift für Gefässkrankheiten Volume: 37 ISSN: 0301-1526 ISO Abbreviation: VASA Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-10-16 Revised Date: 2012-10-19 |
Medline Journal Info:
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Nlm Unique ID: 0317051 Medline TA: Vasa Country: Switzerland |
Other Details:
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Languages: eng Pagination: 281-4 Citation Subset: IM |
Affiliation:
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Division of Angiology and Vascular Surgery, Cardiovascular Department, Inselspital Bern, University Hospital and University of Bern, Switzerland. cornelius.warncke@insel.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Mucinous
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complications*,
pathology,
surgery Amputation Anticoagulants / adverse effects* Arterial Occlusive Diseases / etiology*, radiography, therapy Colectomy Colonic Neoplasms / complications*, pathology, surgery Colonoscopy Embolectomy Femoral Artery* / radiography, surgery Heparin / adverse effects* Humans Male Middle Aged Paraneoplastic Syndromes / etiology*, radiography, therapy Suction Thrombectomy Thrombocytopenia / chemically induced*, therapy Thrombolytic Therapy Thrombosis / etiology*, radiography, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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