| A double mutation in the gyrA gene is necessary to produce high levels of resistance to moxifloxacin in Campylobacter spp. clinical isolates. | |
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MedLine Citation:
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PMID: 15876526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare different fluoroquinolones against Campylobacter spp., analysing the molecular mechanisms of resistance. Moxifloxacin exhibited the greatest activity of the quinolones tested, being active against isolates carrying a single mutation in the gyrA gene. High resistance levels to moxifloxacin were related to the presence of a double gyrA mutation. |
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Authors:
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Joaquim Ruiz; Asunción Moreno; M Teresa Jimenez de Anta; Jordi Vila |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 25 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-30 Completed Date: 2005-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: Netherlands |
Other Details:
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Languages: eng Pagination: 542-5 Citation Subset: IM |
Affiliation:
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Centre de Salut Internacional, IDIBAPS, Hospital Clínic, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution
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genetics Anti-Bacterial Agents / pharmacology* Aza Compounds / pharmacology* Campylobacter / drug effects*, genetics DNA Gyrase / drug effects, genetics* Drug Resistance, Bacterial / genetics* Feces / microbiology Humans Microbial Sensitivity Tests Mutation* Quinolines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Aza Compounds; 0/Quinolines; 0/moxifloxacin; EC 5.99.1.-/DNA Gyrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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