| The double-edged effect of autophagy in pancreatic beta cells and diabetes. | |
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MedLine Citation:
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PMID: 20935505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autophagy is an intracellular catabolic system, which enables cells to capture cytoplasmic components for degradation within lysosomes. Autophagy is involved in development, differentiation and tissue remodeling in various organisms, and is also implicated in certain diseases. Recent studies demonstrate that autophagy is necessary to maintain architecture and function of pancreatic beta cells. Altered autophagy is also involved in pancreatic beta cell death. Whether autophagy plays a protective or harmful role in diabetes is still not clear. In this review, we will summarize the current knowledge about the role of autophagy in pancreatic beta cell and diabetes. |
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Authors:
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Ze-fang Chen; Yan-bo Li; Jun-yong Han; Jing Wang; Jia-jing Yin; Jing-bo Li; Hui Tian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-01-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-30 Completed Date: 2011-03-21 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 12-6 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy* Diabetes Mellitus / pathology* Humans Insulin / secretion Insulin Resistance Insulin-Secreting Cells / pathology* Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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