| A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients. | |
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MedLine Citation:
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PMID: 7869442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia in acutely burned patients. DESIGN: Prospective double-blind randomized study of 40 patients. METHODS: Patients with burns from 25% to 65% total body surface were enrolled. r-HuEPO or a placebo was begun within 72 hours of admission. Cell blood count, reticulocyte counts, transfusion requirements, and blood loss were measured. Comparison was carried out by the unpaired t test. MAIN RESULTS: There was no statistically significant difference in hemoglobin, hematocrit, reticulocyte count, ferritin, serum iron, total iron blinding capacity, or transfusion requirements. In patients with burns from 25% to 35%, the reticulocyte counts were statistically significantly higher. CONCLUSION: In our work the administration of r-HuEPO in acutely burned patients did not prevent the development of postburn anemia or decrease transfusion requirements. Increased erythropoiesis in smaller burns (25% to 35%) was observed and may indicate a reason for further study. |
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Authors:
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J M Still; K Belcher; E J Law; W Thompson; M Jordan; M Lewis; J Saffle; J Hunt; G F Purdue; J P Waymack |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of trauma Volume: 38 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-03-30 Completed Date: 1995-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: AIM; IM |
Affiliation:
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Augusta Regional Medical Center, Georgia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia / etiology, prevention & control* Blood Transfusion Burns / complications*, physiopathology Double-Blind Method Erythropoietin / therapeutic use* Female Humans Male Middle Aged Prospective Studies Recombinant Proteins / therapeutic use Reticulocyte Count |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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