Document Detail


A double blind trial of gefarnate and placebo in the treatment of gastric ulcer.
MedLine Citation:
PMID:  790358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-five patients with chronic gastric ulcers were treated as out-patients in a double-blind comparison of gefarnate (geranyl farnesylacetate), 50 mg four times daily, with the same number of dummy capsules daily for five weeks. The mean percentage reduction in ulcer size assessed by radiography was 70-4 per cent in the gefarnate patients compared with 27-8 per cent in those receiving placebo capsules. This difference is statistically significant (p less than 0-05, with a two-tailed test). No change in the electrolyte balance occurred in any of the patients and no side-effects were reported. These results suggest that gefarnate promotes the healing of gastric ulcers in ambulant patients. Its apparent absence of side-effects makes it a safe ans useful drug.
Authors:
P B Newcomb; W D Stone; P C Richardson; P M Smith; A Gent; B Donovan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Practitioner     Volume:  217     ISSN:  0032-6518     ISO Abbreviation:  Practitioner     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404245     Medline TA:  Practitioner     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  435-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Fatty Acids, Unsaturated / administration & dosage,  therapeutic use
Female
Humans
Male
Middle Aged
Placebos
Smoking
Stomach Ulcer / drug therapy*
Terpenes / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Placebos; 0/Terpenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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