Document Detail


A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria.
MedLine Citation:
PMID:  3311440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 100 male Zambian patients with symptomatic falciparum malaria were treated with either two tablets of mefloquine plus sulfadoxine-pyrimethamine (Fansimef) or three tablets of sulfadoxine-pyrimethamine (Fansidar) as a single dose. The patients were kept under observation from day 0 (day of treatment) to day 28 and all were cured. An S-type of response was seen in all patients; one patient in the Fansimef group inexplicably remained positive for Plasmodium falciparum trophozoites until day 6. There were no cases of recrudescence.The rate of clearance of parasitaemia was similar in both groups. The rate of clearance of fever was marginally faster in the Fansimef group. Side-effects such as pruritus, diarrhoea and abdominal pain occurred after both drugs but were mild and transient; tolerance was slightly better with Fansimef. Severe orthostatic hypotension occurred in 20% of the Fansidar patients and in only 2% of the Fansimef patients; this was reversed by bed rest. Haematological and biochemical parameters were generally not modified in an undesirable manner by the administration of these drugs.
Authors:
J M Ekue; D E Phiri; U K Sheth; M Mukunyandela
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  65     ISSN:  0042-9686     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-02     Completed Date:  1987-12-02     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  369-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Animals
Antimalarials / administration & dosage,  therapeutic use*
Child
Double-Blind Method
Drug Combinations / administration & dosage,  therapeutic use
Humans
Malaria / drug therapy*
Male
Mefloquine* / analogs & derivatives*
Middle Aged
Plasmodium falciparum
Pyrimethamine / administration & dosage,  therapeutic use*
Quinolines / administration & dosage,  therapeutic use*
Random Allocation
Sulfadoxine / administration & dosage,  therapeutic use*
Sulfanilamides / therapeutic use*
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Drug Combinations; 0/Quinolines; 0/Sulfanilamides; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 53230-10-7/Mefloquine; 58-14-0/Pyrimethamine; 69191-18-0/mefloquine-sulfadoxine-pyrimethamine
Comments/Corrections

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