| A double-blind study with misoprostol in the treatment of active duodenal ulcer | |
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MedLine Citation:
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PMID: 3937407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Misoprostol (Mi, a double blind study in the treatment of active duodenal ulcer (DU). The purpose of the paper was to evaluate the effect of Mi vs. Placebo (Pl) without antacids, assessing at the same time side effects and histological alterations. Thirty five patients with active DU diagnosed by endoscopy and photography (performed on days, 0, 14 and 28) were studied. They received 4 doses/day of Mi 100 mcg, or Pl double blind. In each control, biochemical studies in blood and urine were performed. Acetaminophen, 500 mg was the only analgesic allowed. Six patients were excluded. Of the remaining 29 patients, 15 received Mi and 14 Pl. There was no difference in healing at the 14 day stage. At the 28 day stage there was complete healing of the ulcer in 66.6%, and reduction of the ulcer diameter of 89% those who received Mi. The healing rate was 28.5% and reduction of the ulcer diameter of 31% on those patients who received placebo. There were no biochemical alterations or side effects. There was no significative difference between biopsies taken from pylorus and antrum. The consumption of acetaminophen was similar to both groups. It is concluded that Mi has a healing effect similar to H2 blocking agents, accelerating the healing of active DU, without side effects and biochemical changes. |
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Authors:
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P A Mazure; J N Cosen; J E Ciccia; L O Colombato; A Luis; J F Arguto; A Boffi |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; English Abstract; Journal Article |
Journal Detail:
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Title: Acta gastroenterologica Latinoamericana Volume: 15 ISSN: 0300-9033 ISO Abbreviation: Acta Gastroenterol. Latinoam. Publication Date: 1985 |
Date Detail:
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Created Date: 1986-03-13 Completed Date: 1986-03-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0261505 Medline TA: Acta Gastroenterol Latinoam Country: ARGENTINA |
Other Details:
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Languages: spa Pagination: 13-24 Citation Subset: IM |
Vernacular Title:
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Estudio doble ciego con misoprostol en el tratamiento de la úlcera duodenal activa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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administration & dosage Adolescent Adult Age Factors Aged Alprostadil / analogs & derivatives*, pharmacology, therapeutic use Anti-Ulcer Agents / therapeutic use* Clinical Trials as Topic Double-Blind Method Duodenal Ulcer / drug therapy*, pathology Female Gastric Acid / secretion Humans Male Middle Aged Misoprostol Sex Factors Wound Healing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 103-90-2/Acetaminophen; 59122-46-2/Misoprostol; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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