Document Detail

A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients.
MedLine Citation:
PMID:  12013198     Owner:  NLM     Status:  MEDLINE    
Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to apply the cream at least once daily for 30 days. Adverse skin reactions and changes in skin dryness were assessed by the patient and a dermatologist. Adverse skin reactions such as smarting (a sharp local superficial sensation) were felt significantly less among patients using the 20% glycerin cream compared with the urea-saline cream, because 10% of the patients judged the smarting as severe or moderate when using glycerin cream, whereas 24% did so using urea-saline cream (p < 0.0006). No differences were found regarding skin reactions such as stinging, itching and dryness/irritation. The study showed equal effects on skin dryness as judged by the patients and the dermatologist. In conclusion, a glycerin containing cream appears to be a suitable alternative to urea/sodium chloride in the treatment of atopic dry skin.
Marie Lodén; Anna-Carin Andersson; Chris Anderson; Ing-Marie Bergbrant; Thomas Frödin; Hans Ohman; Mari-Helen Sandström; Tore Särnhult; Ewa Voog; Berndt Stenberg; Eva Pawlik; Anna Preisler-Häggqvist; Ake Svensson; Magnus Lindberg
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  82     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  45-7     Citation Subset:  IM    
ACO Hud AB, Stockholm, Sweden.
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MeSH Terms
Administration, Topical
Dermatitis, Atopic / complications,  diagnosis,  drug therapy*
Dermatologic Agents / administration & dosage*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Combinations
Eczema / complications,  diagnosis,  drug therapy
Follow-Up Studies
Glycerol / administration & dosage*
Middle Aged
Reference Values
Severity of Illness Index
Skin Absorption / drug effects
Sodium Chloride / administration & dosage*
Statistics, Nonparametric
Treatment Outcome
Urea / administration & dosage*
Water Loss, Insensible / drug effects
Reg. No./Substance:
0/Dermatologic Agents; 0/Drug Combinations; 0/Ointments; 56-81-5/Glycerol; 57-13-6/Urea; 7647-14-5/Sodium Chloride

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