Document Detail

The double-blind sham-controlled study of high-frequency rTMS (20 Hz) for negative symptoms in schizophrenia: negative results.
MedLine Citation:
PMID:  16648775     Owner:  NLM     Status:  MEDLINE    
The high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the prefrontal cortex is a promising method for the treatment of negative symptoms of schizophrenia. Using double-blind sham-controlled parallel design, we evaluated the effect of HF-rTMS over the left dorsolateral prefrontal cortex (DLPFC) on negative symptoms in patients with schizophrenia. Sixteen schizophrenia patients with predominantly negative symptoms on stable antipsychotic medication were treated with 20 Hz rTMS (90% of motor threshold, 2000 stimuli per session) over ten days within 2 weeks with six weeks follow-up. The effect was assessed using PANSS, CGI, MADRS and neuropsychological tests. We failed to find any significant effect of active rTMS. Sham rTMS showed a trend for improvement over time on positive and negative subscales of PANSS and MADRS. Between-group comparisons failed to reveal any significant differences on any rating scales except a positive subscale of PANSS after 8 weeks. Results from our study did not confirm that HF-rTMS over the left DLPCF affects the negative symptoms of schizophrenia and alternative rTMS approaches are discussed.
Tomás Novák; Jirí Horácek; Pavel Mohr; Miloslav Kopecek; Lucie Skrdlantová; Monika Klirova; Mabel Rodriguez; Filip Spaniel; Colleen Dockery; Cyril Höschl
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  27     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:    2006 Feb-Apr
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Psychiatric Centre Prague, Charles University, 3rd School of Medicine in Prague, Czech Republic.
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MeSH Terms
Double-Blind Method
Neuropsychological Tests
Psychiatric Status Rating Scales
Schizophrenia / therapy*
Schizophrenic Psychology
Transcranial Magnetic Stimulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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