Document Detail


A double-blind, randomized, stratified controlled study of the treatment of tinea imbricata with oral terbinafine or itraconazole.
MedLine Citation:
PMID:  8186139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the efficacy of the new fungicidal allylamine antimycotic, terbinafine, with the triazole antimycotic, itraconazole, in patients with chronic tinea imbricata. Forty-three patients received terbinafine 250 mg daily, and 40 received itraconazole 100 mg daily, for 4 weeks. A total of 72 patients were eligible for follow-up at weeks 5 and 17. Of these, four patients, all from the itraconazole group, did not respond either clinically or mycologically. All of the remaining 68 patients were clinically and mycologically cured. No adverse effects were reported in either group. Terbinafine was assessed as having a superior clinical and mycological cure rate to itraconazole after 4 weeks (P = 0.05) with borderline statistical significance. In addition, after 13 weeks of follow-up, terbinafine provided a significantly reduced rate of reinfection/relapse from further T. concentricum infection compared with itraconazole (P < 0.001). This superior protective effect may be explained by the fungicidal activity and the long persistance in the skin of terbinafine, and indicates the need for higher doses of itraconazole in this particular infection.
Authors:
U Budimulja; K Kuswadji; S Bramono; J Basuki; L S Judanarso; S Untung; S Widagdo; Rohprabowo; Wydianto; D Koesanto
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of dermatology     Volume:  130 Suppl 43     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-23     Completed Date:  1994-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  29-31     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, University of Indonesia, Jakarta.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Aged
Antifungal Agents / administration & dosage*
Child
Child, Preschool
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Indonesia / epidemiology
Itraconazole / administration & dosage*
Male
Middle Aged
Naphthalenes / administration & dosage*
Recurrence
Tinea / drug therapy*,  epidemiology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthalenes; 84625-61-6/Itraconazole; 91161-71-6/terbinafine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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