Document Detail

A double-blind, randomized, parallel group study of omeprazole and ranitidine in Korean patients with gastric ulcer.
MedLine Citation:
PMID:  8003642     Owner:  NLM     Status:  MEDLINE    
The efficacy of the proton pump inhibitor omeprazole, 20 mg every morning, was compared with that of the H2-receptor antagonist ranitidine, 150 mg every morning and at bedtime, in a double-blind randomized parallel group study in 250 patients with gastric or prepyloric ulcers. At both 4 and 8 weeks, significantly more patients had healed ulcers in the omeprazole group than the ranitidine group, whether the results were analysed on a per-protocol or an intention-to-treat basis. At 4 weeks, 74% of patients in the omeprazole group were healed compared with 51% in the ranitidine group (P = 0.001), and at 8 weeks the corresponding values were 99 and 82% (P = 0.001, per-protocol cohort). Omeprazole treatment and small ulcer size significantly increased the probability of healing, but smoking had no significant effect. Patients in the omeprazole group had significantly fewer occurrences of daytime epigastric pain during the first 4 weeks than the ranitidine group (P = 0.0037), as shown by their diary cards. Both treatments were well tolerated.
K W Choi; H S Sun; C M Yoon; K N Park; Y I Min; R Chang; S I Lee; J M Chung; U S Yang; E C Wong
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  9     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1994-07-20     Completed Date:  1994-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  118-23     Citation Subset:  IM    
Seoul National University, Korea.
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MeSH Terms
Double-Blind Method
Middle Aged
Omeprazole / therapeutic use*
Ranitidine / therapeutic use*
Stomach Ulcer / drug therapy*,  physiopathology
Reg. No./Substance:
66357-35-5/Ranitidine; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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