Document Detail


A double-blind, randomized, crossover assessment of blood pressure following administration of avitriptan, sumatriptan, or placebo to patients with mild to moderate hypertension.
MedLine Citation:
PMID:  10214534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of avitriptan, a 5-hydroxytryptamine 1-like (5HT1) receptor agonist for the treatment of migraine, in patients with medicated, controlled, mild to moderate hypertension relative to placebo and sumatriptan. The study was randomized, double-blinded, placebo-controlled, and 4-way crossover in design. Twenty patients (12M, 8F) participated. As required by protocol, all were stable on medications for mild to moderate hypertension, with a supine diastolic blood pressure of < 95 mmHg. Qualified subjects were randomized to receive oral administration of either 75 or 150 mg of avitriptan, 100 mg sumatriptan or placebo during the four treatment visits. Supine blood pressure and pulse rates were recorded up to 24 h after drug administration. Avitriptan 150 mg significantly increased peak diastolic and systolic blood pressure, and mean arterial pressure compared to placebo and sumatriptan 100 mg (p < 0.05). Only those hypertensive patients receiving medication for hypertension should receive anti-migraine medications, such as avitriptan, which are 5HT1-like receptor agonists.
Authors:
S S Jhee; D E Salazar; N F Ford; I E Fulmor; J J Sramek; N R Cutler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  19     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
Affiliation:
California Clinical Trials, Beverly Hills, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / drug effects*,  physiology
Double-Blind Method
Female
Humans
Hypertension / drug therapy*,  physiopathology
Indoles / administration & dosage*
Male
Middle Aged
Sulfonamides / administration & dosage*
Sumatriptan / administration & dosage*
Tryptamines
Chemical
Reg. No./Substance:
0/Indoles; 0/Sulfonamides; 0/Tryptamines; 103628-46-2/Sumatriptan; 171171-42-9/BMS 180048

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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