Document Detail

A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome.
MedLine Citation:
PMID:  18387426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to evaluate the effects of a probiotic combination on symptoms in patients with irritable bowel syndrome (IBS). METHODS: We investigated the efficiency of a probiotic dietary supplement, containing four strains of lactic acid bacteria, on symptoms of IBS. One hundred and sixteen patients with IBS fulfilling the Rome II criteria were randomized in a parallel group, double-blind study to receive a placebo or a probiotic combination (1 x 10(10) cfu once daily) for four weeks. The symptoms that were monitored weekly included discomfort, abdominal pain, and stool frequency and quality. Quality of life was assessed before and at the end of the treatment using the SF36 and FDD-quality-of-life questionnaires. RESULTS: One hundred subjects completed the study (48 probiotic combination, 52 placebo). The probiotic combination was not superior to the placebo in relieving symptoms of IBS (42.6 versus 42.3% improvement). However, the decrease of abdominal pain between the first and the fourth week of treatment was significantly higher in probiotic treated patients (-41.9 versus -24.2%, P=0.048). Interesting findings from the IBS sub-groups were also observed such as a lower pain score at end point in patients with alternating bowel habits (P=0.023) and an increase of stool frequency in the constipated sub-group from the first week of probiotic treatment (P=0.043). CONCLUSIONS: The probiotic combination was not significantly superior to the placebo in relieving symptoms of IBS. Despite the apparent high placebo response, interesting findings from IBS sub-groups were observed in the field of abdominal pain and stool frequency.
S Drouault-Holowacz; S Bieuvelet; A Burckel; M Cazaubiel; X Dray; P Marteau
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Gastroentérologie clinique et biologique     Volume:  32     ISSN:  0399-8320     ISO Abbreviation:  Gastroenterol. Clin. Biol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704825     Medline TA:  Gastroenterol Clin Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
PiLeJe, 37, quai-de-Grenelle, bâtiment Pollux, 75738 Paris cedex 15, France.
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MeSH Terms
Abdominal Pain / physiopathology,  therapy
Bifidobacterium / physiology
Constipation / physiopathology,  therapy
Defecation / physiology
Diarrhea / physiopathology,  therapy
Double-Blind Method
Irritable Bowel Syndrome / physiopathology,  psychology,  therapy*
Lactobacillus / physiology
Lactobacillus acidophilus / physiology
Middle Aged
Probiotics / therapeutic use*
Quality of Life
Streptococcus thermophilus / physiology
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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