Document Detail

A double-blind randomized clinical trial on the effectiveness of a daily glycolic acid 5% formulation in the treatment of photoaging.
MedLine Citation:
PMID:  9598014     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low-strength daily formulations of glycolic acid are widely promoted for the treatment of photoaging. However, there are few clinical studies that objectively confirm the benefits of such formulations. OBJECTIVE: The purpose of this study was to determine the effectiveness of a 5% unneutralized formulation of glycolic acid in the treatment of facial and neck photoaging. METHODS: Seventy-five volunteers were recruited to take part in this double-blind randomized placebo-controlled clinical study. Participants applied either the 5% glycolic acid cream or the placebo cream to the face and neck for a period of 3 months. Pre- and posttreatment clinical assessments of photoaging effects were made by the same physician and were analyzed for statistical significance. RESULTS: Overall there were trends towards greater improvement or less worsening in the glycolic acid group for all clinical assessments for photoaging. There was statistically significant improvement favoring the active-cream in general skin texture and discoloration. There was a trend favoring glycolic acid in reduction of wrinkles, but this did not achieve statistical significance. CONCLUSION: Unneutralized 5% glycolic acid topical cream when used on a regular daily basis can improve some photoaging effects.
P K Thibault; J Wlodarczyk; A Wenck
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  24     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-10     Completed Date:  1998-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-7; discussion 577-8     Citation Subset:  IM    
Central Vein and Cosmetic Medical Center, Broadmeadow, New South Wales, Australia.
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MeSH Terms
Administration, Topical
Double-Blind Method
Drug Administration Schedule
Glycolates / administration & dosage*,  therapeutic use
Middle Aged
Skin Aging / drug effects*
Reg. No./Substance:
0/Glycolates; 0/Ointments; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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