Document Detail

A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition.
MedLine Citation:
PMID:  10369709     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: To determine whether the inclusion of 20 g free glutamine as part of the nitrogen source of parenteral feeds reduces length of hospital stay or mortality. METHODS: In a randomised, double blind, controlled trial in 168 patients clinically accepted for parenteral nutrition, standard feeds were compared with feeds in which 3.8 g of the total nitrogen was replaced with the equivalent 20 g glutamine. A minimum of 11 g nitrogen/day was used in all patients. Daily intakes of energy and nitrogen were determined using a validated computer protocol and were similar for the two groups. All feeds included trace elements, vitamins, electrolytes, and minerals. RESULTS: A total of 85 patients received a median of eight (interquartile range 5-13) daily feeds containing glutamine while 83 received a median of eight (5-15) standard feeds. No difference between groups was detected for infective complications. Twenty control patients and 14 who had received glutamine died during their hospital stay (NS). Median length of stay was 32 (23-52) days on glutamine, which was not significantly different from the control value of 35 (25-55) days. Glutamine was associated with a significant (p<0.03) reduction in length of stay in surgical patients (45 days (range 29-81) versus 30 days (range 19-54)). CONCLUSION: The benefit from glutamine supplementation of parenteral feeds as used in this trial has not been proved. Supplementation may have advantages in surgical patients and in haematological malignancy. Further trials are required.
J Powell-Tuck; C P Jamieson; G E Bettany; O Obeid; H V Fawcett; C Archer; D L Murphy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  45     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-17     Completed Date:  1999-09-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  AIM; IM    
Rank Department of Human Nutrition, St Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, London, UK.
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MeSH Terms
Aged, 80 and over
Cause of Death
Double-Blind Method
Glutamine / blood,  therapeutic use*
Hospital Mortality
Intensive Care / methods
Length of Stay
Middle Aged
Parenteral Nutrition / methods*
Postoperative Care / methods
Treatment Outcome
Reg. No./Substance:
Comment In:
Gut. 1999 Jul;45(1):6-7   [PMID:  10369693 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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