Document Detail

A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infants.
MedLine Citation:
PMID:  17684214     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Growth faltering during infancy is a characteristic of life in developing countries. Previous studies have shown that small-intestine mucosal enteropathy, accompanied by endotoxemia and a persistent systemic inflammatory response, accounts for up to 64% of the growth faltering in Gambian infants. OBJECTIVE: The objective was to test whether glutamine, with its putative trophic effects on enterocytes, immune cells, and intestinal integrity, can accelerate the repair of the intestine, lower immunostimulation, and reduce growth faltering. DESIGN: Ninety-three infants aged 4-10 mo from the West Kiang region of The Gambia were studied in a double-blind, double-placebo, controlled trial. Glutamine (0.25 mg/kg body wt) or a placebo that contained an isonitrogenous, isoenergetic mix of nonessential amino acids was orally administered twice daily throughout the 5-mo rainy season. Anthropometric measurements were made monthly during the supplementation period and for 6 mo after supplementation. Intestinal permeability was measured monthly (by determining the ratio of lactulose to mannitol), and finger-prick blood samples were collected for the analysis of plasma proteins on 3 occasions. RESULTS: Gambian infants showed a seasonal deterioration in growth and persistently elevated acute phase protein concentrations and intestinal permeability. Oral supplementation with glutamine did not improve growth (x +/- SE: weight gain, 60 +/- 19 and 69 +/- 20 g/mo; length gain, 1.01 +/- 0.05 and 0.95 +/- 0.03 cm/mo) or intestinal permeability [lactulose:mannitol ratio: 0.29 (95% CI: 0.23, 0.35) and 0.26 (95% CI: 0.21, 0.32)] in the glutamine and placebo groups, respectively. It also had no effect on infant morbidity or on plasma concentrations of immunoglobulins or acute phase proteins. CONCLUSION: Glutamine supplementation failed to improve growth or intestinal status in malnourished Gambian infants.
Elizabeth A Williams; Marinos Elia; Peter G Lunn
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  86     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-7     Citation Subset:  AIM; IM    
Human Nutrition Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom.
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MeSH Terms
Acute-Phase Proteins / metabolism
Amino Acids / pharmacology
Blood Proteins / metabolism
Body Weight
Child, Preschool
Developing Countries
Dietary Supplements*
Double-Blind Method
Fructose / pharmacology
Glutamine / therapeutic use*
Intestinal Absorption
Lactulose / metabolism
Mannitol / metabolism
Weight Gain
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Amino Acids; 0/Blood Proteins; 0/Placebos; 30237-26-4/Fructose; 4618-18-2/Lactulose; 56-85-9/Glutamine; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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