| A double-blind, placebo-controlled, glutamine-supplementation trial in growth-faltering Gambian infants. | |
| | |
MedLine Citation:
|
PMID: 17684214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Growth faltering during infancy is a characteristic of life in developing countries. Previous studies have shown that small-intestine mucosal enteropathy, accompanied by endotoxemia and a persistent systemic inflammatory response, accounts for up to 64% of the growth faltering in Gambian infants. OBJECTIVE: The objective was to test whether glutamine, with its putative trophic effects on enterocytes, immune cells, and intestinal integrity, can accelerate the repair of the intestine, lower immunostimulation, and reduce growth faltering. DESIGN: Ninety-three infants aged 4-10 mo from the West Kiang region of The Gambia were studied in a double-blind, double-placebo, controlled trial. Glutamine (0.25 mg/kg body wt) or a placebo that contained an isonitrogenous, isoenergetic mix of nonessential amino acids was orally administered twice daily throughout the 5-mo rainy season. Anthropometric measurements were made monthly during the supplementation period and for 6 mo after supplementation. Intestinal permeability was measured monthly (by determining the ratio of lactulose to mannitol), and finger-prick blood samples were collected for the analysis of plasma proteins on 3 occasions. RESULTS: Gambian infants showed a seasonal deterioration in growth and persistently elevated acute phase protein concentrations and intestinal permeability. Oral supplementation with glutamine did not improve growth (x +/- SE: weight gain, 60 +/- 19 and 69 +/- 20 g/mo; length gain, 1.01 +/- 0.05 and 0.95 +/- 0.03 cm/mo) or intestinal permeability [lactulose:mannitol ratio: 0.29 (95% CI: 0.23, 0.35) and 0.26 (95% CI: 0.21, 0.32)] in the glutamine and placebo groups, respectively. It also had no effect on infant morbidity or on plasma concentrations of immunoglobulins or acute phase proteins. CONCLUSION: Glutamine supplementation failed to improve growth or intestinal status in malnourished Gambian infants. |
| | |
Authors:
|
Elizabeth A Williams; Marinos Elia; Peter G Lunn |
Related Documents
:
|
22609294 - Neonatal jaundice. 18797704 - Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of mono... 17462494 - Anthropometric and laboratory assessment of very low birth weight infants: the most hel... 17983994 - Assessment of breastfeeding and infant growth. 15136104 - Superior outcomes of microsurgical vasectomy reversal in men with the same female partn... 1712934 - Birth outcomes, health problems, and neglect with prenatal exposure to cocaine. |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 86 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-08 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 421-7 Citation Subset: AIM; IM |
Affiliation:
|
Human Nutrition Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute-Phase Proteins
/
metabolism Amino Acids / pharmacology Blood Proteins / metabolism Body Weight Child, Preschool Developing Countries Dietary Supplements* Double-Blind Method Female Fructose / pharmacology Gambia Glutamine / therapeutic use* Humans Intestinal Absorption Lactulose / metabolism Mannitol / metabolism Placebos Weight Gain |
| Chemical | |
Reg. No./Substance:
|
0/Acute-Phase Proteins; 0/Amino Acids; 0/Blood Proteins; 0/Placebos; 30237-26-4/Fructose; 4618-18-2/Lactulose; 56-85-9/Glutamine; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Randomized comparison of 3 types of micronutrient supplements for home fortification of complementar...
Next Document: Genetic and environmental influences on children's food neophobia.